Tapentadol Immediate Release Versus Oxycodone Immediate Release for Treatment of Acute Low Back Pain
نویسندگان
چکیده
منابع مشابه
Tapentadol immediate release versus oxycodone immediate release for treatment of acute low back pain.
BACKGROUND Tapentadol has demonstrated analgesic efficacy across a range of pain conditions. OBJECTIVE In a head-to-head study of up to 10 days in duration, the analgesic efficacy and tolerability of tapentadol immediate release (IR) versus oxycodone IR using a flexible dosing regimen were compared in patients with acute low back pain (LBP) and associated radicular leg pain. STUDY DESIGN Ra...
متن کاملDose conversion between tapentadol immediate and extended release for low back pain.
BACKGROUND Tapentadol, a novel, centrally acting analgesic with 2 mechanisms of action (mu-opioid receptor agonism and norepinephrine reuptake inhibition), has been developed in an immediate-release (IR) and an extended-release (ER) formulation. Determination of the safety and equianalgesic ratios for conversion between formulations is important for physicians with patients taking tapentadol IR...
متن کاملPain relief and tolerability balance of immediate release tapentadol or oxycodone treatment for patients with moderate to severe osteoarthritis or low back pain.
PURPOSE Opioid treatment effectiveness may be best compared using definitions of treatment response, which combine measures assessing pain reduction and the occurrence of adverse events (AEs). This analysis of data from two phase III clinical trials was conducted to examine the pain relief and tolerability (PRT) balance of immediate release (IR) tapentadol and oxycodone in patients with moderat...
متن کاملTapentadol immediate release: a new treatment option for acute pain management
The undertreatment of acute pain is common in many health care settings. Insufficient management of acute pain may lead to poor patient outcomes and potentially life-threatening complications. Opioids provide relief of moderate to severe acute pain; however, therapy with pure μ-opioid agonists is often limited by the prevalence of side effects, particularly opioid-induced nausea and vomiting. T...
متن کاملTapentadol immediate release: a review of its use in the treatment of moderate to severe acute pain.
Tapentadol (Nucynta) is an orally active, centrally acting synthetic analgesic that is thought to exert its analgesic effects via two mechanisms of action (mu-opioid receptor agonism and norepinephrine reuptake inhibition). In the US, the immediate-release (IR) formulation of the drug is approved for the relief of moderate to severe acute pain in patients aged > or =18 years. In the EU, the dru...
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ژورنال
عنوان ژورنال: Pain Physician
سال: 2013
ISSN: 2150-1149,1533-3159
DOI: 10.36076/ppj.2013/16/e237